Anti-MAPKAPK5 Antibody

Rs. 68,577.00
SKU stj72940

General Information

Product name Anti-MAPKAPK5 Antibody
Short Description Goat polyclonal to MAPKAPK5
Description
Applications ELISA, WB, IP, IHC
Dilution range
Protein Name Anti-MAPKAPK5 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 54.2 kDa
Database Links
Alternative Names MAPKAPK5MAP kinase-activated protein kinase 5 antibodyMAPK-activated protein kinase 5 antibodyMAPKAP kinase 5 antibodyMAPKAP-K5 antibodyMAPKAPK-5 antibodyMK-5 antibodyMK5MAPKAPK5 antibodyPRAK
Function Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation, Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB, Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53, Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation, Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB, Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4), Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement,
Cellular Localization Cytoplasm, Nucleus,
Tissue Specificity Expressed ubiquitously,
Swiss-Prot Key

 

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