Anti-MARCH1 Antibody

Rs. 57,098.00
SKU stj71445

General Information

Product name Anti-MARCH1 Antibody
Short Description Goat polyclonal to MARCH1
Description
Applications ELISA
Dilution range
Protein Name Anti-MARCH1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 32.3 kDa
Database Links
Alternative Names MARCH1E3 ubiquitin-protein ligase MARCH1 MARCH1 antibodyRNF171
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system,
Cellular Localization Golgi apparatus, trans-Golgi network membrane
Tissue Specificity Expressed in antigen presenting cells, apcs, located in lymph nodes and spleen, also expressed in lung, expression is high in follicular b-cells, moderate in dendritic cells and low in splenic t-cells,
Swiss-Prot Key

 

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