Anti-MARCH1 antibody

Rs. 50,211.00
SKU stj94007

General Information

Product name Anti-MARCH1 antibody
Short Description
Description Rabbit polyclonal to MARCH1.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-MARCH1 antibody
Immunogen Synthesized peptide derived from human 40603.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 32.308 kDa
Database Links
Alternative Names E3 ubiquitin-protein ligase MARCH1 antibody
Membrane-associated RING finger protein 1 antibody
Membrane-associated RING-CH protein I antibody
MARCH-I antibody
RING finger protein 171 antibody
RING-type E3 ubiquitin transferase MARCH1
MARCH1 antibody
RNF171 antibody
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Cellular Localization Golgi apparatus, trans-Golgi network membrane Lysosome membrane Cytoplasmic vesicle membrane Late endosome membrane Early endosome membrane Cell membrane
Tissue Specificity Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.
Swiss-Prot Key

 

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