Anti-MATK Antibody

Rs. 45,619.00
SKU stj28734

General Information

Product name Anti-MATK Antibody
Short Description Rabbit polyclonal to MATK
Description The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-MATK Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 352-466 of human MATK (NP_647611.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 56.5 kDa
Database Links
Alternative Names MATKMegakaryocyte-associated tyrosine-protein kinase MATK antibodyCTK antibodyHYL
Function Could play a significant role in the signal transduction of hematopoietic cells, May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site, It may play an inhibitory role in the control of T-cell proliferation.
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in various myeloid cell lines, detected in brain and lung
Swiss-Prot Key

 

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