Anti-MAVS Antibody

Rs. 45,619.00
SKU stj28331

General Information

Product name Anti-MAVS Antibody
Short Description Rabbit polyclonal to MAVS
Description This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:20 - 1:100
Protein Name Anti-MAVS Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human MAVS (NP_065797.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 56.5 kDa
Database Links
Alternative Names MAVSMitochondrial antiviral-signaling protein antibodyMAVS antibodyCARD adapter inducing interferon beta antibodyCardif antibodyInterferon beta promoter stimulator protein 1 antibodyIPS-1 antibodyPutative NF-kappa-B-activating protein 031N antibodyVirus-induced-signaling adapter antibodyVISAMAVS antibodyIPS1 antibodyKIAA1271 antibodyVISA
Function Required for innate immune defense against viruses, Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5), Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state, Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response, May activate the same pathways following detection of extracellular dsRNA by TLR3, May protect cells from apoptosis.
Cellular Localization Mitochondrion outer membrane
Tissue Specificity Present in t-cells, monocytes, epithelial cells and hepatocytes (at protein level), ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
Swiss-Prot Key

 

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