Anti-MDM2 (isoform) Antibody

Rs. 68,577.00
SKU stj70807

General Information

Product name Anti-MDM2 (isoform) Antibody
Short Description Goat polyclonal to MDM2 (isoform)
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-MDM2 (isoform) Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 55.2 kDa
Database Links
Alternative Names MDM2E3 ubiquitin-protein ligase Mdm2 MDM2
Function E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation ,
Cellular Localization Nucleus, nucleoplasm, Cytoplasm, Nucleus, nucleolus,
Tissue Specificity Ubiquitous, isoform mdm2-a, isoform mdm2-b, isoform mdm2-c, isoform mdm2-d, isoform mdm2-e, isoform mdm2-f and isoform mdm2-g are observed in a range of cancers but absent in normal tissues
Swiss-Prot Key

 

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