Anti-MECP2 Antibody

Rs. 45,619.00
SKU stj27661

General Information

Product name Anti-MECP2 Antibody
Short Description Rabbit polyclonal to MECP2
Description DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-MECP2 Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MECP2 (NP_004983.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 52.4 kDa
Database Links
Alternative Names MECP2Methyl-CpG-binding protein 2 antibodyMeCp-2 protein antibodyMeCp2MECP2
Function Chromosomal protein that binds to methylated DNA, It can bind specifically to a single methyl-CpG pair, It is not influenced by sequences flanking the methyl-CpGs, Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A, Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Cellular Localization Nucleus
Tissue Specificity Present in all adult somatic tissues tested
Swiss-Prot Key

 

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