Anti-MEF2A Antibody

Rs. 57,098.00
SKU stj29820

General Information

Product name Anti-MEF2A Antibody
Short Description Rabbit polyclonal to MEF2A
Description The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC,ICC,FC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
ICC 1:50 - 1:200
FC 1:20 - 1:50
Protein Name Anti-MEF2A Antibody
Immunogen Recombinant protein of human MEF2A
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 54.8 kDa
Database Links
Alternative Names MEF2AMyocyte-specific enhancer factor 2A antibodySerum response factor-like protein 1MEF2A antibodyMEF2
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes, Also involved in the activation of numerous growth factor- and stress-induced genes, Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival, Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription, In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation, Associates with chromatin to the ZNF16 promoter.
Cellular Localization Nucleus
Tissue Specificity Isoform mef2 and isoform mefa are expressed only in skeletal and cardiac muscle and in the brain, isoform rsrfc4 and isoform rsrfc9 are expressed in all tissues examined.
Swiss-Prot Key

 

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