Anti-mei-41 Antibody

Rs. 57,098.00
SKU stj72762

General Information

Product name Anti-mei-41 Antibody
Short Description Goat polyclonal to mei-41 (Drosophila melanogaster)
Description
Applications ELISA
Dilution range
Protein Name Anti-mei-41 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 289.3 kDa
Database Links
Alternative Names Anti-mei-41 (Drosophila melanogaster) Antibody
Function Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor, Recognizes the substrate consensus sequence [ST]-Q, Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination, Phosphorylates grp/CHK1, Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism, Essential for the DNA damage checkpoint in larval imaginal disks and neuroblasts and for the DNA replication checkpoint in the embryo, Has also an essential role during early nuclear divisions in embryos, where it is required to delay mitosis in response to incomplete DNA replication, Also plays an important role during meiosis, where it may monitor double-strand-break repair during meiotic crossing over, to regulate the progression of prophase I, and to enforce metaphase I delay observed at the end of oogenesis,
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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