Anti-MEK-1 antibody

Rs. 50,211.00
SKU stj94078

General Information

Product name Anti-MEK-1 antibody
Short Description
Description Rabbit polyclonal to MEK-1.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-MEK-1 antibody
Immunogen Synthesized peptide derived from human MEK-1 around the non-phosphorylation site of T292.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 43 kDa
Database Links
Alternative Names MEK-1
Dual specificity mitogen-activated protein kinase kinase 1 antibody
MAP kinase kinase 1 antibody
MAPKK 1 antibody
MKK1 antibody
ERK activator kinase 1 antibody
MAPK/ERK kinase 1 antibody
MEK 1 antibody
MEK1 antibody
PRKMK1 antibody
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body Cytoplasm Nucleus Membrane. Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis . Membrane localization is probably regulated by its interaction with KSR1 .
Tissue Specificity Widely expressed, with extremely low levels in brain.
Swiss-Prot Key

 

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