Anti-MEK-4 antibody

Rs. 50,211.00
SKU stj94084

General Information

Product name Anti-MEK-4 antibody
Short Description
Description Rabbit polyclonal to MEK-4.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:20000
Protein Name Anti-MEK-4 antibody
Immunogen Synthesized peptide derived from human MEK-4 around the non-phosphorylation site of S80.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 44 kDa
Database Links
Alternative Names MEK-4
Dual specificity mitogen-activated protein kinase kinase 4 antibody
MAP kinase kinase 4 antibody
MAPKK 4 antibody
JNK-activating kinase 1 antibody
MAPK/ERK kinase 4 antibody
MEK 4 antibody
SAPK/ERK kinase 1 antibody
SEK1 antibody
Stress-activated protein kinase kinase 1 antibody
SAPK kinase 1 antibody
SAPKK-1 antibody
SAPKK1 antibody
c-Jun N-terminal kinase kinase 1 antibody
JNKK antibody
JNKK1 antibody
MEK4 antibody
MKK4 antibody
PRKMK4 antibody
SEK1 antibody
SERK1 antibody
SKK1 antibody
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Cellular Localization Cytoplasm Nucleus
Tissue Specificity Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Swiss-Prot Key

 

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