Anti-MEK-7 antibody

Rs. 50,211.00
SKU stj94090

General Information

Product name Anti-MEK-7 antibody
Short Description
Description Rabbit polyclonal to MEK-7.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:20000
Protein Name Anti-MEK-7 antibody
Immunogen Synthesized peptide derived from human MEK-7 around the non-phosphorylation site of T275.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 47 kDa
Database Links
Alternative Names MEK-7
Dual specificity mitogen-activated protein kinase kinase 7 antibody
MAP kinase kinase 7 antibody
MAPKK 7 antibody
JNK-activating kinase 2 antibody
MAPK/ERK kinase 7 antibody
MEK 7 antibody
Stress-activated protein kinase kinase 4 antibody
SAPK kinase 4 antibody
SAPKK-4 antibody
SAPKK4 antibody
c-Jun N-terminal kinase kinase 2 antibody
JNK kinase 2 antibody
JNKK 2 antibody
JNKK2 antibody
MEK7 antibody
MKK7 antibody
PRKMK7 antibody
SKK4 antibody
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Cellular Localization Nucleus. Cytoplasm
Tissue Specificity Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
Swiss-Prot Key

 

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