Anti-MMP2 Antibody

Rs. 45,619.00
SKU stj28003

General Information

Product name Anti-MMP2 Antibody
Short Description Rabbit polyclonal to MMP2
Description This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-MMP2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MMP2 (NP_004521.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 73.9 kDa
Database Links
Alternative Names MMP272 kDa type IV collagenaseMMP2 antibodyCLG4A
Function Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture, As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction, Also cleaves KISS at a Gly-|-Leu bond, Appears to have a role in myocardial cell death pathways, Contributes to myocardial oxidative stress by regulating the activity of GSK3beta, Cleaves GSK3beta in vitro, Involved in the formation of the fibrovascular tissues in association with MMP14
Cellular Localization Secreted, extracellular space, extracellular matrix, Membrane, Nucleus, Cytoplasm, Mitochondrion
Tissue Specificity Produced by normal skin fibroblasts, pex is expressed in a number of tumors including gliomas, breast and prostate.
Swiss-Prot Key

 

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