Anti-Mnk2 antibody

Rs. 50,211.00
SKU stj94173

General Information

Product name Anti-Mnk2 antibody
Short Description
Description Rabbit polyclonal to Mnk2.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-Mnk2 antibody
Immunogen Synthesized peptide derived from human Mnk2.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 51 kDa
Database Links
Alternative Names Mnk2
MAP kinase-interacting serine/threonine-protein kinase 2 antibody
MAP kinase signal-integrating kinase 2 antibody
MAPK signal-integrating kinase 2 antibody
Mnk2 antibody
GPRK7 antibody
MNK2 antibody
Function Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Cellular Localization Isoform 2: Nucleus, PML body.. Isoform 1: Cytoplasm.
Tissue Specificity Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
Swiss-Prot Key

 

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