Anti-MORF4L1 Antibody

Rs. 45,619.00
SKU stj29151

General Information

Product name Anti-MORF4L1 Antibody
Short Description Rabbit polyclonal to MORF4L1
Description
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-MORF4L1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 41.5 kDa
Database Links
Alternative Names MORF4L1Mortality factor 4-like protein 1 antibodyMORF-related gene 15 protein antibodyProtein MSL3-1 antibodyTranscription factor-like protein MRG15MORF4L1 antibodyMRG15 antibodyFWP006 antibodyHSPC008 antibodyHSPC061 antibodyPP368
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400, NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage, Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones, Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC), Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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