Anti-MSH3 Antibody

Rs. 45,619.00
SKU stj27648

General Information

Product name Anti-MSH3 Antibody
Short Description Rabbit polyclonal to MSH3
Description The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-MSH3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 127.4 kDa
Database Links
Alternative Names MSH3DNA mismatch repair protein Msh3 antibodyhMSH3 antibodyDivergent upstream protein antibodyDUP antibodyMismatch repair protein 1 antibodyMRP1MSH3 antibodyDUC1 antibodyDUG
Function Component of the post-replicative DNA mismatch repair system (MMR), Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair, When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs, MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long, After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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