Anti-MST-3 antibody

Rs. 50,211.00
SKU stj94269

General Information

Product name Anti-MST-3 antibody
Short Description
Description Rabbit polyclonal to MST-3.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-MST-3 antibody
Immunogen Synthesized peptide derived from human MST-3
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 50 kDa
Database Links
Alternative Names MST-3
Serine/threonine-protein kinase 24 antibody
Mammalian STE20-like protein kinase 3 antibody
MST-3 antibody
STE20-like kinase MST3 antibody
Serine/threonine-protein kinase 24 36 kDa subunit antibody
Mammalian STE20-like protein kinase 3 N-terminal antibody
MST3/N antibody
Serine/threonine-protein kinase 24 12 kDa subunit antibody
Mammalian STE20-like protein kinase 3 C-terminal antibody
MST3/C antibody
MST3 antibody
STK3 antibody
Function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation . Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Cellular Localization Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Tissue Specificity Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
Swiss-Prot Key

 

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