Anti-MST1R Antibody

Rs. 61,689.00
SKU stj24622

General Information

Product name Anti-MST1R Antibody
Short Description Rabbit polyclonal to MST1R
Description This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-MST1R Antibody
Immunogen A synthetic peptide of human MST1R
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 152.2 kDa
Database Links
Alternative Names MST1RMacrophage-stimulating protein receptor antibodyMSP receptorMST1R antibodyPTK8 antibodyRON
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand, Regulates many physiological processes including cell survival, migration and differentiation, Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1, Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC, RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site, Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages, Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Cellular Localization Membrane
Tissue Specificity Expressed in colon, skin, lung and bone marrow.
Swiss-Prot Key

 

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