Anti-MTDH Antibody

Rs. 45,619.00
SKU stj29926

General Information

Product name Anti-MTDH Antibody
Short Description Rabbit polyclonal to MTDH
Description
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-MTDH Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MTDH (NP_848927.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 63.8 kDa
Database Links
Alternative Names MTDHProtein LYRIC antibody3D3/LYRIC antibodyAstrocyte elevated gene-1 protein antibodyAEG-1 antibodyLysine-rich CEACAM1 co-isolated protein antibodyMetadherin antibodyMetastasis adhesion proteinMTDH antibodyAEG1 antibodyLYRIC
Function Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically, Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor, Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion, Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium, Induces chemoresistance.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland, overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Swiss-Prot Key

 

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