Anti-MTF2 Antibody

Rs. 45,619.00
SKU stj29157

General Information

Product name Anti-MTF2 Antibody
Short Description Rabbit polyclonal to MTF2
Description
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-MTF2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MTF2 (NP_001157864.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 67.1 kDa
Database Links
Alternative Names MTF2Metal-response element-binding transcription factor 2 antibodyMetal regulatory transcription factor 2 antibodyMetal-response element DNA-binding protein M96 antibodyPolycomb-like protein 2 antibodyhPCl2MTF2 antibodyPCL2
Function Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity, Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation, Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells, Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex, In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally, Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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