Anti-MXI1 Antibody

Rs. 45,619.00
SKU stj28744

General Information

Product name Anti-MXI1 Antibody
Short Description Rabbit polyclonal to MXI1
Description Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-MXI1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 76-295 of human MXI1 (NP_569157.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 26.1 kDa
Database Links
Alternative Names MXI1Max-interacting protein 1 antibodyMax interactor 1 antibodyClass C basic helix-loop-helix protein 11 antibodybHLHc11MXI1 antibodyBHLHC11
Function Transcriptional repressor, MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3', MXI1 thus antagonizes MYC transcriptional activity by competing for MAX
Cellular Localization Nucleus
Tissue Specificity High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle
Swiss-Prot Key

 

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