Anti-MYLK Antibody

Rs. 68,577.00
SKU stj71215

General Information

Product name Anti-MYLK Antibody
Short Description Goat polyclonal to MYLK
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-MYLK Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 210.7 kDa
Database Links
Alternative Names MYLKMyosin light chain kinase antibodysmooth muscle antibodyMLCK antibodysmMLCKMYLK antibodyMLCK antibodyMLCK1 antibodyMYLK1
Function Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC), Also regulates actin-myosin interaction through a non-kinase activity, Phosphorylates PTK2B/PYK2 and myosin light-chains, Involved in the inflammatory response (e,g, apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma, Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance, Necessary for gastrointestinal motility, Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements, In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells, Critical participant in signaling sequences that result in fibroblast apoptosis, Plays a role in the regulation of epithelial cell survival, Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure, Mediates RhoA-dependent membrane blebbing, Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane, Promotes cell migration (including tumor cells) and tumor metastasis, PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI), May regulate optic nerve head astrocyte migration, Probably involved in mitotic cytoskeletal regulation, Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring, Mediates burn-induced microvascular barrier injury
Cellular Localization Cytoplasm
Tissue Specificity Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific, non-muscle isoform 2 is the dominant splice variant expressed in various tissues, telokin has been found in a wide variety of adult and fetal tissues, accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (tnf),
Swiss-Prot Key

 

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