Anti-NANOS1 Antibody

Rs. 68,577.00
SKU stj70675

General Information

Product name Anti-NANOS1 Antibody
Short Description Goat polyclonal to NANOS1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-NANOS1 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 30.2 kDa
Database Links
Alternative Names NANOS1Nanos homolog 1 antibodyNOS-1NANOS1 antibodyNOS1
Function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets, Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin, Up-regulates the production of MMP14 to promote tumor cell invasion,
Cellular Localization Cytoplasm, perinuclear region
Tissue Specificity Testis and ovary (at protein level), predominantly expressed in testis, specifically expressed during germline development, in adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline, also expressed during meiosis in spermatocytes, not present in late, post-meiotic stage germ cells, expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells, expressed at high levels only in the e-cadherin deficient cell lines, highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness,
Swiss-Prot Key

 

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