Anti-NCR3 Antibody

Rs. 45,619.00
SKU stj29233

General Information

Product name Anti-NCR3 Antibody
Short Description Rabbit polyclonal to NCR3
Description The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:100
Protein Name Anti-NCR3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human NCR3 (NP_667341.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 21.6 kDa
Database Links
Alternative Names NCR3Natural cytotoxicity triggering receptor 3 antibodyActivating natural killer receptor p30 antibodyNatural killer cell p30-related protein antibodyNK-p30 antibodyNKp30 antibodyCD antigen CD337NCR3 antibody1C7 antibodyLY117
Function Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1, Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands, It controls, for instance, NK cells cytotoxicity against tumor cells, Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Cellular Localization Cell membrane
Tissue Specificity Selectively expressed by all resting and activated nk cells and weakly expressed in spleen.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF