Anti-NDE1 Antibody

Rs. 45,619.00
SKU stj29192

General Information

Product name Anti-NDE1 Antibody
Short Description Rabbit polyclonal to NDE1
Description This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-NDE1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human NDE1 (NP_060138.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37.7 kDa
Database Links
Alternative Names NDE1Nuclear distribution protein nudE homolog 1 antibodyNudENDE1 antibodyNUDE
Function Required for centrosome duplication and formation and function of the mitotic spindle, Essential for the development of the cerebral cortex, May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain, Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron, A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Cellular Localization Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Chromosome, centromere, kinetochore, Cytoplasm, cytoskeleton, spindle, Cleavage furrow.
Tissue Specificity Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.
Swiss-Prot Key

 

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