Anti-NEIL1 Antibody

Rs. 45,619.00
SKU stj28391

General Information

Product name Anti-NEIL1 Antibody
Short Description Rabbit polyclonal to NEIL1
Description This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications IF
Dilution range IF 1:50 - 1:200
Protein Name Anti-NEIL1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 187-476 of human NEIL1 (NP_001243481.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 43.7 kDa
Database Links
Alternative Names NEIL1Endonuclease 8-like 1 NEIL1
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil, Has marginal activity towards 8-oxoguanine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates, Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches, Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

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