Anti-NEIL1 antibody

Rs. 50,211.00
SKU stj94395

General Information

Product name Anti-NEIL1 antibody
Short Description
Description Rabbit polyclonal to NEIL1.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:20000
Protein Name Anti-NEIL1 antibody
Immunogen Synthesized peptide derived from human NEIL1
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 44 kDa
Database Links
Alternative Names Endonuclease 8-like 1 antibody
DNA glycosylase/AP lyase Neil1 antibody
DNA- antibody
apurinic or apyrimidinic site lyase Neil1 antibody
Endonuclease VIII-like 1 antibody
FPG1 antibody
Nei homolog 1 antibody
NEH1 antibody
Nei-like protein 1 antibody
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus Chromosome. During mitosis, associates with centrosomes and condensed chromatin.
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

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