Anti-NEK2 Antibody

Rs. 45,619.00
SKU stj27308

General Information

Product name Anti-NEK2 Antibody
Short Description Rabbit polyclonal to NEK2
Description This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-NEK2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human NEK2 (NP_001191112.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51.8 kDa
Database Links
Alternative Names NEK2Serine/threonine-protein kinase Nek2 NEK2 antibodyNEK2A antibodyNLK1
Function Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells, Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes, Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80, Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1, Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2, Phosphorylates: PPP1CC
Cellular Localization Nucleus, Nucleus, nucleolus, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue Specificity Isoform 1 and isoform 2 are expressed in peripheral blood t-cells and a wide variety of transformed cell types, isoform 1 and isoform 4 are expressed in the testis, up-regulated in various cancer cell lines, as well as primary breast tumors.
Swiss-Prot Key

 

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