Anti-NELFE Antibody

Rs. 45,619.00
SKU stj29086

General Information

Product name Anti-NELFE Antibody
Short Description Rabbit polyclonal to NELFE
Description The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-NELFE Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human NELFE (NP_002895.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 43.2 kDa
Database Links
Alternative Names NELFENegative elongation factor E antibodyNELF-E antibodyRNA-binding protein RDNELFE antibodyRD antibodyRDBP
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II, The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex, The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II, Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA, Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
Cellular Localization Nucleus
Tissue Specificity Widely expressed, expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
Swiss-Prot Key

 

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