Anti-Nesprin-3 antibody

Rs. 50,211.00
SKU stj94404

General Information

Product name Anti-Nesprin-3 antibody
Short Description
Description Rabbit polyclonal to Nesprin-3.
Applications WB,IF,ELISA
Dilution range WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000
Protein Name Anti-Nesprin-3 antibody
Immunogen Synthesized peptide derived from human Nesprin-3
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 130 kDa
Database Links
Alternative Names Nesprin-3
Nesprin-3 antibody
KASH domain-containing protein 3 antibody
KASH3 antibody
Nuclear envelope spectrin repeat protein 3 antibody
C14orf139 antibody
C14orf49 antibody
LINC00341 antibody
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Cellular Localization Nucleus outer membrane Nucleus envelope Rough endoplasmic reticulum
Tissue Specificity Expressed in aortic endothelial cells (at protein level).
Swiss-Prot Key

 

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