Anti-NEU1 Antibody

Rs. 45,619.00
SKU stj28221

General Information

Product name Anti-NEU1 Antibody
Short Description Rabbit polyclonal to NEU1
Description The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-NEU1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 156-415 of human NEU1 (NP_000425.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.5 kDa
Database Links
Alternative Names NEU1Sialidase-1 NEU1 antibodyNANH
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids, To be active, it is strictly dependent on its presence in the multienzyme complex, Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Cellular Localization Lysosome membrane
Tissue Specificity Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver, weakly expressed in brain.
Swiss-Prot Key

 

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