Anti-NFKBIB Antibody

Rs. 45,619.00
SKU stj28344

General Information

Product name Anti-NFKBIB Antibody
Short Description Rabbit polyclonal to NFKBIB
Description The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-NFKBIB Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-356 of human NFKBIB (NP_002494.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37.8 kDa
Database Links
Alternative Names NFKBIBNF-kappa-B inhibitor beta antibodyNF-kappa-BIB antibodyI-kappa-B-beta antibodyIkB-B antibodyIkB-beta antibodyIkappaBbeta antibodyThyroid receptor-interacting protein 9 antibodyTR-interacting protein 9 antibodyTRIP-9NFKBIB antibodyIKBB antibodyTRIP9
Function Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm, However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation, Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation
Cellular Localization Cytoplasm
Tissue Specificity Expressed in all tissues examined
Swiss-Prot Key

 

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