Anti-NGEF Antibody

Rs. 61,689.00
SKU stj26742

General Information

Product name Anti-NGEF Antibody
Short Description Rabbit polyclonal to NGEF
Description
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-NGEF Antibody
Immunogen A synthetic Peptide of human NGEF
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 82.5 kDa
Database Links
Alternative Names NGEFEphexin-1 antibodyEph-interacting exchange protein antibodyNeuronal guanine nucleotide exchange factorNGEF
Function Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42, Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis, Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation, Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Cellular Localization Cytoplasm.
Tissue Specificity Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus, also detected in lung.
Swiss-Prot Key

 

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