Anti-NLRC4 Antibody

Rs. 45,619.00
SKU stj29519

General Information

Product name Anti-NLRC4 Antibody
Short Description Rabbit polyclonal to NLRC4
Description This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-NLRC4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human NLRC4 (NP_067032.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 116.2 kDa
Database Links
Alternative Names NLRC4NLR family CARD domain-containing protein 4 antibodyCARD antibodyLRR antibodyand NACHT-containing protein antibodyClan protein antibodyCaspase recruitment domain-containing protein 12 antibodyIce protease-activating factor antibodyIpafNLRC4 antibodyCARD12 antibodyCLAN antibodyCLAN1 antibodyIPAF antibodyUNQ6189/PRO20215
Function Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
Cellular Localization Cytoplasm.
Tissue Specificity Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen, isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver, isoform 4 is only detected in brain
Swiss-Prot Key

 

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