Anti-NA Antibody

Rs. 45,619.00
SKU stj27619

General Information

Product name Anti-NA Antibody
Short Description Rabbit polyclonal to NLRP3
Description This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-NA Antibody
Immunogen Recombinant protein of human NLRP3
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 118.2 kDa
Database Links
Alternative Names NLRP3NACHT antibodyLRR and PYD domains-containing protein 3 antibodyAngiotensin/vasopressin receptor AII/AVP-like antibodyCaterpiller protein 1.1 antibodyCLR1.1 antibodyCold-induced autoinflammatory syndrome 1 protein antibodyCryopyrin antibodyPYRIN-containing APAF1-like protein 1NLRP3 antibodyC1orf7 antibodyCIAS1 antibodyNALP3 antibodyPYPAF1
Function As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation, In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5), Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu, Activation of NLRP3 inflammasome is also required for HMGB1 secretion.
Cellular Localization Cytoplasm, cytosol.
Tissue Specificity Predominantly expressed in macrophages, also expressed in dendritic cells, b- and t-cells (at protein level).
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF