Anti-NLRP3 Antibody

Rs. 57,098.00
SKU stj73244

General Information

Product name Anti-NLRP3 Antibody
Short Description Goat polyclonal to NLRP3
Description
Applications ELISA
Dilution range
Protein Name Anti-NLRP3 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 118.2 kDa
Database Links
Alternative Names NLRP3NACHT antibodyLRR and PYD domains-containing protein 3 antibodyAngiotensin/vasopressin receptor AII/AVP-like antibodyCaterpiller protein 1.1 antibodyCLR1.1 antibodyCold-induced autoinflammatory syndrome 1 protein antibodyCryopyrin antibodyPYRIN-containing APAF1-like protein 1NLRP3 antibodyC1orf7 antibodyCIAS1 antibodyNALP3 antibodyPYPAF1
Function As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation, In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5), Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu, Activation of NLRP3 inflammasome is also required for HMGB1 secretion ,
Cellular Localization Cytoplasm, cytosol,
Tissue Specificity Predominantly expressed in macrophages, also expressed in dendritic cells, b- and t-cells (at protein level) ,
Swiss-Prot Key

 

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