Anti-NOTCH1 Antibody

Rs. 45,619.00
SKU stj29951

General Information

Product name Anti-NOTCH1 Antibody
Short Description Rabbit polyclonal to NOTCH1
Description This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Protein Name Anti-NOTCH1 Antibody
Immunogen A synthetic peptide of human NOTCH1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 272.5 kDa
Database Links
Alternative Names NOTCH1Neurogenic locus notch homolog protein 1 antibodyNotch 1 antibodyhN1 antibodyTranslocation-associated notch protein TAN-1NOTCH1 antibodyTAN1
Function Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination, Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus, Affects the implementation of differentiation, proliferation and apoptotic programs, Involved in angiogenesis
Cellular Localization Cell membrane
Tissue Specificity In fetal tissues most abundant in spleen, brain stem and lung, also present in most adult tissues where it is found mainly in lymphoid tissues
Swiss-Prot Key

 

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