Anti-NR2C2 Antibody

Rs. 45,619.00
SKU stj28505

General Information

Product name Anti-NR2C2 Antibody
Short Description Rabbit polyclonal to NR2C2
Description This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-NR2C2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human NR2C2 (NP_003289.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 65.4 kDa
Database Links
Alternative Names NR2C2Nuclear receptor subfamily 2 group C member 2 antibodyOrphan nuclear receptor TAK1 antibodyOrphan nuclear receptor TR4 antibodyTesticular receptor 4NR2C2 antibodyTAK1 antibodyTR4
Function Orphan nuclear receptor that can act as a repressor or activator of transcription, An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways, May regulate gene expression during the late phase of spermatogenesis, Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Plays a fundamental role in early embryonic development and embryonic stem cells, Required for normal spermatogenesis and cerebellum development, Appears to be important for neurodevelopmentally regulated behavior (By similarity), Activates transcriptional activity of LHCG, Antagonist of PPARA-mediated transactivation.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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