Anti-NR5A2 Antibody

Rs. 45,619.00
SKU stj28333

General Information

Product name Anti-NR5A2 Antibody
Short Description Rabbit polyclonal to NR5A2
Description The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-NR5A2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 206-495 of human NR5A2 (NP_003813.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 61.3 kDa
Database Links
Alternative Names NR5A2Nuclear receptor subfamily 5 group A member 2 antibodyAlpha-1-fetoprotein transcription factor antibodyB1-binding factor antibodyhB1F antibodyCYP7A promoter-binding factor antibodyHepatocytic transcription factor antibodyLiver receptor homolog 1 antibodyLRH-1NR5A2 antibodyB1F antibodyCPF antibodyFTF
Function Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis, Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism, Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex expression in liver, May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Cellular Localization Nucleus
Tissue Specificity Abundantly expressed in pancreas, less in liver, very low levels in heart and lung, expressed in the hep-g2 cell line, isoform 1 and isoform 2 seem to be present in fetal and adult liver and hep-g2 cells
Swiss-Prot Key

 

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