Anti-NTRK2 Antibody

Rs. 61,689.00
SKU stj24835

General Information

Product name Anti-NTRK2 Antibody
Short Description Mouse monoclonal to NTRK2
Description This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,FC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Anti-NTRK2 Antibody
Immunogen A synthetic peptide of human NTRK2
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 92 kDa
Database Links
Alternative Names NTRK2BDNF/NT-3 growth factors receptor NTRK2 antibodyTRKB
Function Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation, Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Cellular Localization Cell membrane
Tissue Specificity Isoform trkb is expressed in the central and peripheral nervous system, in the central nervous system (cns), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord, in the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia, isoform trkb-t1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart, isoform trkb-t-shc is predominantly expressed in the brain.
Swiss-Prot Key

 

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