Anti-NTRK3 Antibody

Rs. 45,619.00
SKU stj28405

General Information

Product name Anti-NTRK3 Antibody
Short Description Rabbit polyclonal to NTRK3
Description This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-NTRK3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human NTRK3 (NP_001007157.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 94.4 kDa
Database Links
Alternative Names NTRK3NT-3 growth factor receptor NTRK3 antibodyTRKC
Function Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Cellular Localization Membrane
Tissue Specificity Widely expressed but mainly in nervous tissue, isoform 2 is expressed at higher levels in adult brain than in fetal brain
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF