Anti-OPTN Antibody

Rs. 45,619.00
SKU stj24869

General Information

Product name Anti-OPTN Antibody
Short Description Rabbit polyclonal to OPTN
Description This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-OPTN Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP_068815.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 65.9 kDa
Database Links
Alternative Names OPTNOptineurin antibodyE3-14.7K-interacting protein antibodyFIP-2 antibodyHuntingtin yeast partner L antibodyHuntingtin-interacting protein 7 antibodyHIP-7 antibodyHuntingtin-interacting protein L antibodyNEMO-related protein antibodyOptic neuropathy-inducing protein antibodyTranscription factor IIIA-interacting protein antibodyTFIIIA-IntPOPTN antibodyFIP2 antibodyGLC1E antibodyHIP7 antibodyHYPL antibodyNRP
Function Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 May constitute a cellular target for adenovirus E3 14,7 and Bluetongue virus protein NS3 to inhibit innate immune response.
Cellular Localization Cytoplasm, perinuclear region, Golgi apparatus, Golgi apparatus, trans-Golgi network, Cytoplasmic vesicle, autophagosome, Cytoplasmic vesicle, Recycling endosome.
Tissue Specificity Present in aqueous humor of the eye (at protein level), highly expressed in trabecular meshwork, expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Swiss-Prot Key

 

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