Anti-OSM Antibody

Rs. 45,619.00
SKU stj27935

General Information

Product name Anti-OSM Antibody
Short Description Rabbit polyclonal to OSM
Description This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-OSM Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 26-252 of human OSM (NP_065391.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 28.5 kDa
Database Links
Alternative Names OSMOncostatin-M antibodyOSMOSM
Function Growth regulator, Inhibits the proliferation of a number of tumor cell lines, Stimulates proliferation of AIDS-KS cells, It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells, Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST), Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Cellular Localization Secreted
Tissue Specificity
Swiss-Prot Key

 

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