Anti-P4HTM Antibody

Rs. 45,619.00
SKU stj27896

General Information

Product name Anti-P4HTM Antibody
Short Description Rabbit polyclonal to P4HTM
Description The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-P4HTM Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 294-563 of human P4HTM (NP_808807.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 56.7 kDa
Database Links
Alternative Names P4HTMTransmembrane prolyl 4-hydroxylase antibodyP4H-TMP4HTM antibodyPH4
Function Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, Hydroxylates HIF1A at 'Pro-402' and 'Pro-564', May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland, expressed at lower levels in epiphyseal cartilage and in fibroblasts.
Swiss-Prot Key

 

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