Anti-PA2G4 Antibody

Rs. 45,619.00
SKU stj27329

General Information

Product name Anti-PA2G4 Antibody
Short Description Rabbit polyclonal to PA2G4
Description This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-PA2G4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-394 of human PA2G4 (NP_006182.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 43.8 kDa
Database Links
Alternative Names PA2G4Proliferation-associated protein 2G4 antibodyCell cycle protein p38-2G4 homolog antibodyhG4-1 antibodyErbB3-binding protein 1PA2G4 antibodyEBP1
Function May play a role in a ERBB3-regulated signal transduction pathway, Seems be involved in growth regulation, Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG), Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity, Binds RNA, Associates with 28S, 18S and 5,8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA, May be involved in regulation of intermediate and late steps of rRNA processing, May be involved in ribosome assembly, Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity), Regulates cell proliferation, differentiation, and survival, Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
Cellular Localization Cytoplasm
Tissue Specificity Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level), isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed