Anti-PADI4 Antibody

Rs. 68,577.00
SKU stj70617

General Information

Product name Anti-PADI4 Antibody
Short Description Goat polyclonal to PADI4
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-PADI4 Antibody
Immunogen N Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 74.1 kDa
Database Links
Alternative Names PADI4Protein-arginine deiminase type-4 PADI4 antibodyPAD4 antibodyPADI5 antibodyPDI5
Function Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance, Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci), Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance, Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci, Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription, Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1,
Cellular Localization Cytoplasm, Nucleus, Cytoplasmic granule,
Tissue Specificity Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes,
Swiss-Prot Key

 

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