Anti-NA Antibody

Rs. 45,619.00
SKU stj29827

General Information

Product name Anti-NA Antibody
Short Description Rabbit polyclonal to PARP1
Description This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Applications WB,IHC,IF
Dilution range WB 1:1000 - 1:3000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-NA Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 113.1 kDa
Database Links
Alternative Names PARP1Poly polymerase 1 antibodyPARP-1PARP1 antibodyADPRT antibodyPPOL
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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