Anti-PARP3 Antibody

Rs. 61,689.00
SKU stj24901

General Information

Product name Anti-PARP3 Antibody
Short Description Rabbit polyclonal to PARP3
Description The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-PARP3 Antibody
Immunogen A synthetic peptide of human PARP3
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.1 kDa
Database Links
Alternative Names PARP3Poly polymerase 3 antibodyPARP-3 antibodyhPARP-3PARP3 antibodyADPRT3 antibodyADPRTL3
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks, May link the DNA damage surveillance network to the mitotic fidelity checkpoint, Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication, Binds DNA, May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Cellular Localization Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Tissue Specificity Widely expressed
Swiss-Prot Key

 

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