Anti-PAX5 Antibody

Rs. 45,619.00
SKU stj24910

General Information

Product name Anti-PAX5 Antibody
Short Description Rabbit polyclonal to PAX5
Description This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:1000 - 1:3000
Protein Name Anti-PAX5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 150-300 of human PAX5 (NP_057953.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 42.1 kDa
Database Links
Alternative Names PAX5Paired box protein Pax-5 antibodyB-cell-specific transcription factor antibodyBSAPPAX5
Function May play an important role in B-cell differentiation as well as neural development and spermatogenesis, Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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