Anti-PBK Antibody

Rs. 45,619.00
SKU stj25678

General Information

Product name Anti-PBK Antibody
Short Description Rabbit polyclonal to PBK
Description This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-PBK Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.1 kDa
Database Links
Alternative Names PBKLymphokine-activated killer T-cell-originated protein kinase PBK antibodyTOPK
Function Phosphorylates MAP kinase p38, Seems to be active only in mitosis, May also play a role in the activation of lymphoid cells, When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Cellular Localization
Tissue Specificity Expressed in the testis and placenta, in the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF